Yes! I had this happen about two months ago. My allergist and internist insist it had nothing to do with the shots. I also don’t have any documented food allergies- though I did eat an Impossible Burger for the first time that night and others have documented allergic reactions to it.

I’m absolutely convinced the shots are partly to blame for my GI issue— I was on the second to last vial and had been having bad local reactions for two weeks before this happened. That being said, I’m now continuing the course of my shots, just at a much slower pace than before.

Yes, I had allergy shots for about 10 years. They really helped my reaction to pollen, leaves, trees and dust. But now years later I’m having lots of food allergies, citrus, tomato, corn, dairy. They gave me such diarrhea I had to take a leave of absence from work. Now am on Fodmap diet which is very limited and can add 1 food item at a time to see what else I’m allergic too. But am still getting sick and had to go back to work. It’s not fun.

Mine have not been as bad as this round I'm on now. The more concentrated it get, the more I break out on a local rash around the injection area. I ended up spreading calamine lotion on a cotton pad and taped it over the area with medical tape or I place and ice pack on it. I have lost sleep. It sometimes get worse with heat.

Have the doctors fine tooth the ingredients of your allergy shots and the exact amounts of the ingredients in each bottle. While they should be consistent, manufacturers can use different methods while making any medication.

I'm going 2 times a week right now. The dosage chart is very gradual. At first because of work my shots were spaced 3 days apart. They're now 1 day apart. I find I'm tolerating them better that way. I had a bad reaction last week but that's only the second time. Seems to be one bad reaction per bottle.
4-5 times a week sounds really extreme. Were your friends allergies really severe?